Correlation of eGFR (estimated Glomerular Filtration Rate) with Potassium Levels in Patients with Diabetes Mellitus with Chronic Kidney Failure Complications

Abstract

Diabetes mellitus is a chronic disease caused by pancreatic metabolic disorders, and is characterized by hyperglycemia due to insulin resistance, insulin deficiency or a combination of both. A common complication in patients with diabetes mellitus is diabetic nephropathy. Diabetic nephropathy is characterized by the presence of microalbuminuria 30 mg/day, then developing into proteinuria accompanied by high blood pressure so that the glomerular filtration rate decreases and causes kidney failure. Chronic kidney failure is characterized by GFR <60 mL/minute/1.73 m2 which lasts for more than three months. eGFR is a more sensitive indicator for measuring kidney damage than serum creatinine because it measures the level of glomerular damage specifically and assesses the filtration function of the kidneys. Decreased kidney function can interfere with potassium metabolism, because potassium excretion is mostly through the kidneys. Disruption of potassium homeostasis can cause hyperkalemia. This study aims to determine the correlation of eGFR with potassium levels in patients with diabetes mellitus who experience complications of chronic kidney failure. The type of research used is observational analytic with a cross-sectional approach. This study was conducted at Syarifah Ambami Rato Ebu Bangkalan Hospital, a type B hospital with A accredited service quality. eGFR examination was carried out using a Cockcroft Gault method and potassium level examination was carried out using the ISE (Ion selective Electrode) method. Data analysis was carried out using the Shapiro Wilk normality test and the Spearman correlation test. The results showed no correlation between eGFR and potassium levels in patients with diabetes mellitus who experienced complications of chronic kidney failure.