Leukocyte and Platelite Cell Counts With C-Reactive Protein (CRP) Values in Dengue Hemorrhagic Fever

Abstract

Dengue hemorrhagic fever is a health problem caused by infection with dengue viruses (DENVs). Hematological examination of the number of leukocyte and platelet cells is carried out because thrombocytopenia, leukopenia and leukocytosis are often found in this infection. Inflammation in Dengue Fever conditions can be detected using C-Reactive Protein (CRP) as an inflammation biomarker. This study aims to determine the correlation between the number of leukocyte and platelet cells with CRP values in Dengue Hemorrhagic Fever patients. The research methodology in this study is correlation analysis using a cross sectional approach. The sample size in this study was 40 blood samples infected with the dengue virus. This research was carried out at the Prima Main Clinic in Surabaya in February - March 2024. Routine hematological examination of leukocyte and platelet cell counts used the Sysmex XP-100 flow cytometer method and examination of CRP values using the Wondfo CRP test using the fluorescence immunoassay (FIA) method. The results of this study showed that 30% of patients experienced leukopenia, 37.5% leukocytosis, 100% thrombocytopenia, 77.5% of patients had high CRP results. The correlation in this study between leukocytes and CRP with a p value of 0.041 and the correlation of platelets with CRP with a p value of 0.00, meaning that there is a relationship between the number of leukocytes and platelets and the value of ¬C-Reactive Protein (CRP) in conditions of Dengue Hemorrhagic Fever infection because (p < 0.05).