Relationship of Sifilis Coinfection With CD4+ Count in PLHIV (People with Human Immunodeficiency Virus)

Abstract

Syphilis is a contagious infection transmitted through sexual contact (STI) and can affect various organs of the body caused by Treponema pallidum. Syphilis increases the chances of HIV transmission. Co-infection in which HIV and Treponema pallidum often occur together is caused by the same transmission pathways and risk factors. so it is quite common in HIV-infected people, Syphilis-HIV co-infection can reduce the number of CD4 + +, causing the condition of the immune system to become worse. The purpose of this study was to determine how the relationship between Syphilis co-infection and the number of CD4+ in ODHIV (People with Human Immunodeficiency). The type of research used was correlation research with a cross sectional design. 20 ODHIV with a history of / still suffering from syphilis were serologically examined for syphilis and CD4+ examination was carried out at the immunology laboratory of BBLabkesmas Surabaya. Data were analyzed by Fisher's exact test, from the results of Fisher's exact test can be seen the significance value = 0.05. The results of the study were 18 respondents out of 20 respondents showed reactive results in the RPR and Anti TP examinations, 2 respondents showed non-reactive results in the RPR examination and Reactive anti TP examination, so that 90% of respondents had syphilis co-infection. The average CD4+ count of the respondents was 713 cells/ul. where the normal value of adult healthy human CD4+ is 500 - 1500 cells/ul. The research data processed with Fisher's exact test resulted in a significant value of 0.521. which means the P value> 0.05. From this study it can be concluded that there is no relationship between syphilis co-infection and CD4+ count in ODHIV (people with Human Immunodeficiency Virus).