Atepa: In Vitro Anticoagulant of Catappa Leaves (Terminalia catappa)

Abstract

Catappa leaves (Terminalia catappa), contain flavonoids, saponins, phenols, and tannins after being tested qualitatively. Flavonoids have strong antioxidant activity. Based on previous studies, this active compound can prevent platelet aggregation in the blood clotting process. Due to this activity, catappa leaf extract has anticoagulant activity. Atepa was made by diluting the extract into several concentration variations, namely 1%, 2%, 3%, 4%, 5%, and 6%. After testing with the Lee White Clotting Time method, it was found that in 1% concentration was able to inhibit the coagulation process. After observing the May-Grunwald Giemsa stain, it can be observed that the blood cells are still shaped according to their characteristics and have not changed. Atepa can prevent coagulation in vitro. The active compound of flavonoids, saponins, and tannins in catappa leaves is a substance that plays an important role in anticoagulation activity. Atepa still requires in vivo testing if it is to be used as an in vivo anticoagulant. Atepa can be redeveloped according to the intended implementation.